Dr. Xiaoliang Sun

Group leader, Bioinformatics and mathematical modelling

Room: 1.316

Althanstraße 14 (UZA I)
1090 Wien
Phone: +43-1-4277-76570
Mobile: +43-677-6264-9211
xiaoliang.sun@univie.ac.at

Research group 

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Brief Bio

Trained in biomedical engineering and bioinformatics, Xiaoliang Sun has worked towards Omics data analysis from 2006. He has applied quantitative approaches such as statistics and mathematical modelling with many omics data including next generation sequencing, transcriptomics, proteomics and metabolomics on multiple scales of biological systems from microbial, plants, animals, and human to ecosystems. He applied machine learning methods to select molecular biomarkers in medical studies, developed algorithms to investigate the casual relationships between primary and secondary metabolism, explored genome-scale metabolic network reconstruction, associated nonlinear dynamics theory with time-series gene expression and studied environmental effects on extracted features from metagenomics data. In mathematical modelling, he developed stochastic differential equations of metabolic pathways. He mathematically solved the inverse Jacobian that are inferred from noisy metabolomics data and thereby constructed a direct link between genotype, phenotype and environments.

Xiaoliang Sun has strong software development experiences. He has developed COVAIN, an omics data analysis software that contains essential statistical analysis workflow from data preprocessing, uni- and multi-variate statistics, supervised classifications, time series, network analysis and inverse Jacobian, as well as multiple Omics integration. He has developed metabolomics software including mzGroupAnalyzer which facilitates the structural annotation and pathway exploration in secondary metabolites, and mzFun which reads from RAW LC-MS-MSn data and performs library compounds matching, deconvolution, peak alignment and quantification. All these software are provided with friendly graphical user interface to ease the analysis difficulty for experimental biologists.

Since 2016 Xiaoliang Sun has been a core member of Vienna Metabolomics Center (http://metabolomics.univie.ac.at). Since 2018 he has been group leader in bioinformatics and mathematical modelling in Department of Molecular Systems Biology of University of Vienna. He is invited reviewer for the journal Bioinformatics and Current Metabolomics.

Curriculum Vitae

1997 – 2001Bachelor in Biomedical Engineering, Southeast University, Nanjing, China
2001 – 2003BioChip Engineer in China Electronics Technology Group Corporation, Nanjing, China
2003 – 2006Master in Bioinformatics, Department of Biomedical Engineering, Southeast University, Nanjing, China
2006 – 2009PhD in Bioinformatics, Max-Planck-Institute for Molecular Plant Physiology, Potsdam, Germany, and University of Potsdam, Germany, 2011
2010 – 2013Project staff and post-doctoral, Department of Molecular Systems Biology, University of Vienna, Austria
2013 – 2015Senior metabolomics scientist in Global Change Research Institute of Academy of Sciences of the Czech Republic, Brno, Czech Republic
2013 – 2016Research Associate in Institute of Integrative Biology, University of Liverpool, UK
Since 2016University Assistant, Vienna Metabolomics Center, University of Vienna, Austria
Since 2018Group Leader Bioinformatics and Mathematical Modelling, Department of Molecular Systems Biology, University of Vienna, Austria