Molecular System Dynamics -
Thomas Naegele group

Room: 1.303
Althanstraße 14 (UZA I)
1090 Vienna, Austria
+43-1-4277-76556
thomas.naegele@univie.ac.at

l.t.r: Lydia Priglinger (Master student), Jakob Weiszmann (PhD student), Mag. Lisa Fürtauer (PhD student), Dipl.-Biol. Dr. Thomas Nägele (group leader)

Research Focus

Molecular System Dynamics

The experimental high-throughput analysis of cellular systems has become an integral part of biological research.Concomitantly, the interpretation of the resulting complex data sets with respect to biochemical regulation and physiological traits lags far behind. The group’s research focus addresses the question how to link such experimental high-throughput data to underlying biochemical and signalling networks, their regulation and related physiological traits. The compilation of our biochemical, physiological and high-throughput techniques are combined with a framework of biomathematical operations ultimately aiming at the detection and characterisation of cellular and organismal outputs.

Key techniques which are applied in the group:
Metabolomics (see also: ViMe – Vienna Metabolomics Center)
Subcellular fractionation techniques
Enzyme kinetics
Mathematical modeling of metabolic networks
Multivariate Statistics

Projects

in situ studies of Arabidopsis thaliana populations (Project Homepage)

Regulation of primary metabolism under oxidative stress (Project Homepage)