Cajanus cajan -a source of PPARγ activators leading to anti-inflammatory and cytotoxic effects

Author(s)
Roswitha Schuster, Wolfgang Holzer, Hannes Doerfler, Wolfram Weckwerth, Helmut Viernstein, Siriporn Okonogi, Monika Mueller
Abstract

Cajanus cajan is an important legume crop in the human diet in many parts of the world. Due to its pharmacological properties, C. cajan is, moreover, used in traditional medicine for treating skin diseases, diabetes, inflammatory disorders and various other dysfunctions. In this study, we focused on the role of peroxisome proliferator-activated receptor gamma (PPARγ) as a potential therapeutic target of Cajanus cajan and its main compounds for the treatment of cancer, inflammation and inflammation-related disorders. The anti-inflammatory potential of C. cajan and its bioactive compounds and their cytotoxicity on the human cervical adenocarcinoma cell line HeLa, the human colorectal adenocarcinoma cell line CaCo-2 and the human breast adenocarcinoma cell line MCF-7 were elucidated. C. cajan and its compounds exerted significant anti-inflammatory activity on lipopolysaccharide-stimulated macrophages, showed good cytotoxic effects on the 3 different cancer cell lines and proved PPARγ activity in vitro. The main active compounds were orientin, pinostrobin and vitexin. Cajaninstilbene acid and pinosylvin monomethylether were identified as novel PPARγ activators. Based on these data, C. cajan provides excellent beneficial medicinal attributes and may be used as a potential food or a pharmaceutical supplement.

Organisation(s)
Department of Pharmaceutical Technology and Biopharmaceutics, Department of Pharmaceutical Chemistry, Department of Ecogenomics and Systems Biology, Large-Instrument Facility for Mass Spectrometry in Life Sciences, Research Platform Vienna Metabolomics Center
Journal
Food & Function: linking the chemistry and physics of food with health and nutrition
Volume
7
Pages
3798-3806
No. of pages
9
ISSN
2042-6496
DOI
https://doi.org/10.1039/c6fo00689b
Publication date
09-2016
Publication status
Published
Peer reviewed
Yes
Austrian Fields of Science 2012
301204 Pharmacognosy, 301206 Pharmacology, 301208 Pharmaceutical technology
ASJC Scopus subject areas
Food Science
Portal url
https://ucris.univie.ac.at/portal/en/publications/cajanus-cajan-a-source-of-ppar-activators-leading-to-antiinflammatory-and-cytotoxic-effects(23dff513-bc08-4ff5-a8a4-bc41b9825102).html