(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII
- Author(s)
- Lenka Kubicova, Gert Bachmann, Wolfram Weckwerth, Vladimir Chobot
- Abstract
Catechin is an extensively investigated plant flavan-3-ol with a beneficial impact on human health that is often associated with antioxidant activities and iron coordination complex formation. The aim of this study was to explore these properties with FeII and FeIII using a combination of nanoelectrospray-mass spectrometry, differential pulse voltammetry, site-specific deoxyribose degradation assay, FeII autoxidation assay, and brine shrimp mortality assay. Catechin primarily favored coordination complex formation with Fe ions of the stoichiometry catechin:Fe in the ratio of 1:1 or 2:1. In the detected Fe–catechin coordination complexes, FeII prevailed. Differential pulse voltammetry, the site-specific deoxyribose degradation, and FeII autoxidation assays proved that coordination complex formation affected catechin’s antioxidant effects. In situ formed Fe–catechin coordination complexes showed no toxic activities in the brine shrimp mortality assay. In summary, catechin has properties for the possible treatment of pathological processes associated with ageing and degeneration, such as Alzheimer’s and Parkinson’s diseases.
- Organisation(s)
- Functional and Evolutionary Ecology, Research Platform Vienna Metabolomics Center
- External organisation(s)
- Universität Wien
- Journal
- Cells
- Volume
- 11
- No. of pages
- 16
- ISSN
- 2073-4409
- DOI
- https://doi.org/10.3390/cells11060958
- Publication date
- 03-2022
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 106034 Phytochemistry, 104002 Analytical chemistry, 106025 Neurobiology, 106031 Plant physiology
- Keywords
- ASJC Scopus subject areas
- Medicine(all)
- Sustainable Development Goals
- SDG 3 - Good Health and Well-being
- Portal url
- https://ucris.univie.ac.at/portal/en/publications/catechina-massspectrometrybased-exploration-coordination-complex-formation-with-feii-and-feiii(9ca1c34c-c66a-4f07-a36d-f1284a743631).html