Effects of endogenous neurotoxin quinolinic acid on reactive oxygen species production by Fenton reaction catalyzed by iron or copper

Author(s)
Lenka Kubicova, Franz Hadacek, Wolfram Weckwerth, Vladimir Chobot
Abstract

The tryptophan metabolite, quinolinic (2,3-pyridinedicarboxylic) acid, is known as an endogenous neurotoxin. Quinolinic acid can form coordination complexes with iron or copper. The effects of quinolinic acid on reactive oxygen species production in the presence of iron or copper were explored by a combination of chemical assays, classical site-specific and ascorbic acid-free variants of the deoxyribose degradation assay, and mass spectrometry (ESI-MS). Quinolinic acid showed evident antioxidant activity in chemical assays, but the effect was more pronounced in the presence of copper as transition metal catalyst than in presence of iron. Nano-ESI-MS confirmed the ability of quinolinic acid to form coordination complexes with iron(II) or copper(II) and quinolinic acid stability against oxidative attack by hydroxyl radicals. The results illustrate a highly milieu-dependent quinolinic acid chemistry when it enters reactions as competitive ligand. (C) 2015 The Authors. Published by Elsevier B.V.

Organisation(s)
Large-Instrument Facility for Mass Spectrometry in Life Sciences
External organisation(s)
Georg-August-Universität Göttingen
Journal
Journal of Organometallic Chemistry
Volume
782
Pages
111-115
No. of pages
5
ISSN
0022-328X
DOI
https://doi.org/10.1016/j.jorganchem.2015.01.030
Publication date
04-2015
Peer reviewed
Yes
Austrian Fields of Science 2012
104013 Natural product chemistry, 106044 Systems biology, 104003 Inorganic chemistry, 106025 Neurobiology
Keywords
Portal url
https://ucris.univie.ac.at/portal/en/publications/effects-of-endogenous-neurotoxin-quinolinic-acid-on-reactive-oxygen-species-production-by-fenton-reaction-catalyzed-by-iron-or-copper(e8e1dfb0-52ca-41ea-a4d8-cdcc1ebf3a07).html