Effects of endogenous neurotoxin quinolinic acid on reactive oxygen species production by Fenton reaction catalyzed by iron or copper
- Author(s)
- Lenka Kubicova, Franz Hadacek, Wolfram Weckwerth, Vladimir Chobot
- Abstract
The tryptophan metabolite, quinolinic (2,3-pyridinedicarboxylic) acid, is known as an endogenous neurotoxin. Quinolinic acid can form coordination complexes with iron or copper. The effects of quinolinic acid on reactive oxygen species production in the presence of iron or copper were explored by a combination of chemical assays, classical site-specific and ascorbic acid-free variants of the deoxyribose degradation assay, and mass spectrometry (ESI-MS). Quinolinic acid showed evident antioxidant activity in chemical assays, but the effect was more pronounced in the presence of copper as transition metal catalyst than in presence of iron. Nano-ESI-MS confirmed the ability of quinolinic acid to form coordination complexes with iron(II) or copper(II) and quinolinic acid stability against oxidative attack by hydroxyl radicals. The results illustrate a highly milieu-dependent quinolinic acid chemistry when it enters reactions as competitive ligand.
- Organisation(s)
- External organisation(s)
- Georg-August-Universität Göttingen
- Journal
- Journal of Organometallic Chemistry
- Volume
- 782
- Pages
- 111-115
- No. of pages
- 5
- ISSN
- 0022-328X
- DOI
- https://doi.org/10.1016/j.jorganchem.2015.01.030
- Publication date
- 04-2015
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 104003 Inorganic chemistry, 104013 Natural product chemistry, 106025 Neurobiology, 106044 Systems biology
- Keywords
- ASJC Scopus subject areas
- Materials Chemistry, Biochemistry, Inorganic Chemistry, Physical and Theoretical Chemistry, Organic Chemistry
- Portal url
- https://ucris.univie.ac.at/portal/en/publications/effects-of-endogenous-neurotoxin-quinolinic-acid-on-reactive-oxygen-species-production-by-fenton-reaction-catalyzed-by-iron-or-copper(e8e1dfb0-52ca-41ea-a4d8-cdcc1ebf3a07).html