A Mathematical Model of the Ultrasound-Assisted Continuous Tubular Crystallization of Aspirin
- Author(s)
- Symeon V. Savvopoulos, Mohammed N. Hussain, Jeroen Jordens, Steffen Waldherr, Tom Van Gerven, Simon Kuhn
- Abstract
Ultrasound-assisted nucleation is a promising method of controlling the crystal length within a narrow range in antisolvent crystallization. This article proposes novel model equations representing crystal nucleation and growth under ultrasound application in the antisolvent system of ethanol (solvent), water (antisolvent), and aspirin (pharmaceutical ingredient). The model considers the enhancement of nucleation by ultrasound, and also accounts for the heat generated from both the application of ultrasound and the mixing of solvent and antisolvent. We further employ a global sensitivity analysis to determine the parameters that have the most significant impact on model outputs before validating multiple experimental case studies that represent crystal growth for different antisolvent contents and initial supersaturation ratios. The model successfully captures the effect of the ultrasound, which is a function of temperature and supersaturation ratio, and has a strong impact on the refinement and the quantity of the crystals. The proposed model offers a practical platform that can be applied to different scales and geometries in continuous crystallization systems using ultrasound.
- Organisation(s)
- Functional and Evolutionary Ecology
- External organisation(s)
- Katholieke Universiteit Leuven
- Journal
- Crystal Growth and Design
- Volume
- 19
- Pages
- 5111-5122
- No. of pages
- 12
- ISSN
- 1528-7483
- DOI
- https://doi.org/10.1021/acs.cgd.9b00466
- Publication date
- 09-2019
- Peer reviewed
- Yes
- Austrian Fields of Science 2012
- 204003 Chemical process engineering
- ASJC Scopus subject areas
- General Chemistry, General Materials Science, Condensed Matter Physics
- Portal url
- https://ucrisportal.univie.ac.at/en/publications/ea4d1d39-514e-42f3-a60d-afc9bc7b4803