Subtopics

Metabolomics in Ecology

Metabolomics unravel contrasting effects of biodiversity on the performance of individual plant species.
Scherling C, Roscher C, Giavalisco P, Schulze ED, Weckwerth W. PLoS One. 2010 Sep 7;5(9):e12569. ... Abstract

Metabolomics in systems biology.
Weckwerth, W. Annu Rev Plant Biol 2003, 54, 669-689. ... Abstract

Differential metabolic networks unravel the effects of silent plant phenotypes.
Weckwerth W, Ehlers-Loureiro M, Wenzel K, and Fiehn O PNAS 2004, 101, 7809–7814. ... full article

An automated GCxGC-TOF-MS protocol for batch-wise extraction and alignment of mass isotopomer matrixes from differential (13)C-labelling experiments: a case study for photoautotrophic-mixotrophic grown Chlamydomonas reinhardtii cells.
Kempa, S., Hummel, J., Schwemmer, T., Pietzke, M., et al. J Basic Microbiol 2009. ... Abstract

A rapid approach for phenotype-screening and database independent detection of cSNP/protein polymorphism using mass accuracy precursor alignment. Proteomics 2008, 8, 4214-25.
Hoehenwarter W, van Dongen JT, Wienkoop S, Steinfath M, Hummel J, Erban A, Sulpice R, Regierer B, Kopka J, Geigenberger P, Weckwerth W. Proteomics 2008, 8, 4214-25 ... Abstract
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Process for the integrated extraction identification, and quantification of metabolites, proteins and RNA to reveal their co-regulation in biochemical networks. Weckwerth, W., Wenzel, K., Fiehn, O.Proteomics 2004, 4, 78-83. ... Abstract
Correlative GC-TOF-MS based metabolite profiling and LC-MS based protein profiling reveal time-related systemic regulation of metabolite-protein networks and improve pattern recognition for multiple biomarker selection. Morgenthal, K., Wienkoop, S., Scholz, M., Selbig, J., Weckwerth, W. Metabolomics 2005, 1, 109-121.
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Integration of metabolomic and proteomic phenotypes: analysis of data covariance dissects starch and RFO metabolism from low and high temperature compensation response in Arabidopsis thaliana.
Wienkoop, S., Morgenthal, K., Wolschin, F., Scholz, M., et al. Mol Cell Proteomics 2008a, 7, 1725-1736. ... Abstract
Integration of metabolomics and proteomics in molecular plant physiology - coping with the complexity by data-dimensionality reduction. Weckwerth, W. Physiol Plantarum 2008, 132, 176-189. ... Abstract
Targeted proteomics for Chlamydomonas reinhardtii combined with rapid subcellular protein fractionation, metabolomics and metabolic flux analyses. Wienkoop S, Weiss J, May P, Kempa S, Irgang S, Recuenco-Munoz L, Pietzke M, Schwemmer T, Rupprecht J, Egelhofer V, Weckwerth W. Mol Biosyst. 2010 Jun 18;6(6):1018-31. ... Abstract

Enrichment of phosphorylated proteins and peptides from complex mixtures using metal oxide/hydroxide affinity chromatography (MOAC). Wolschin, F., Wienkoop, S., Weckwerth, W.
Proteomics 2005, 5, 4389-4397. ... Abstract
ProMEX: a mass spectral reference database for proteins and protein phosphorylation sites. Hummel J, Niemann M, Wienkoop S, Schulze WX, Steinhauser D, Selbig J, Walther D and Weckwerth W. BMC Bioinformatics, 2007, 1-8
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Comparative analysis of phytohormone - responsive phosphoproteins in Arabidopsis thaliana using TiO2-phosphopeptide enrichment and MAPA. Chen Y., Hoehenwarter W. and Weckwerth W. (2010) Plant J. 2010; 63:1-17. ... Abstract
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If the antibody fails – a mass Western approach. Lehmann, U., Wienkoop, S., Tschoep, H., Weckwerth, W.
Plant Journal, 55, 1039–1046. ... Abstract
Targeted proteomics for Chlamydomonas reinhardtii combined with rapid subcellular protein fractionation, metabolomics and metabolic flux analyses. Wienkoop S, Weiss J, May P, Kempa S, Irgang S, Recuenco-Munoz L, Pietzke M, Schwemmer T, Rupprecht J, Egelhofer V, Weckwerth W. Mol Biosyst. 2010 Jun 18;6(6):1018-31.
... Abstract

Metabolomics- and proteomics-assisted genome annotation and analysis of the draft metabolic network of Chlamydomonas reinhardtii. May, P., Wienkoop, S., Kempa, S., Usadel, B., et al. Genetics 2008, 179, 157-166.
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